Toxicologist/Biostatistician
Company: Oak Ridge Associated Universities
Location: Raleigh
Posted on: April 25, 2024
Job Description:
Toxicologist/Biostatistician
Job Locations
US-NC-Raleigh
ID
2023-2521
Category
Science & Engineering
Type
Full Time
Overview
ORAU has a job opportunity for a Toxicologist/Biostatistician. This
position will support of the overall functions of the National
Institute of Environmental Health Sciences, (NIEHS). This contract
will last for 5 years. The position is contingent on award of an
upcoming contract with NIEHS. ORAU offers a competitive total
compensation plan with salary and benefits commensurate with the
role. The project is expected to begin in January, 2024. For
interest in future opportunity, apply today! ORAU has been
providing scientific and technical talent staffing solutions and
designing, managing, and evaluating jobs and internships for more
than 70 years. ORAU assists in connecting the best and most diverse
group of students, recent graduates, faculty and professionals with
world-class fellowships, internships and job opportunities, whether
in national laboratories, research institutions, federal government
offices or private sector R&D departments.
Responsibilities
Supporting multi-disciplinary
projects requiring bioinformatics analysis of toxicology and
environmental health researchSupporting transcriptomics and
toxicogenomics studies The project team will conduct toxicogenomics
studies (transcriptomics applied to toxicology) as part of short
term, long term and/or in vitro exposure studies followed by use of
microarray or Next Generation Sequencing (NGS) platforms. This
requirement focuses on transcriptomic data including mRNA
transcripts, microRNA, and non-coding transcript data.
Toxicogenomic studies generate vast amounts of gene expression data
that require bioinformatics data analysis such as quality control
statistics, normalization, identification of differentially
expressed genes and assignment of genes to pathways and networks
for biological analysis/interpretation. The candidate shall provide
bioinformatics and data mining support for the analysis of RNA-Seq
and microarray data. Familiarity with other toxicogenomics database
resources (e.g., GEO, SRA) and browsers (e.g., UCSC browser) is
required. To support transcriptomic and toxicogenomics studies, the
candidate will extract data from a variety of sources including
large public and private databases. For example, any Tox21
chemicals and transcript expression data may be extracted from
databases; data integration and mining may be requested from
documents in EPA dockets. It is anticipated that approximately 5-7
transcriptomics studies per year will need bioinformatics support.
Supporting High Throughput
Transcriptomics (HTT) As the project team embarks upon the next
phase of Tox21 program, the DNTP is conducting transcriptomics
experiments using high throughput platforms to screen large numbers
of chemicals (See Ramaiahgari et al 2019, ToxSci 169:553-566). For
this purpose, the candidate shall assist with selection of key
genes to be included in the screening as well as selection of
relevant platforms for screening experiments. The candidate may
participate in experimental design, gene or cell line selection and
bioinformatics analysis of the resulting data. The data to be
generated will depend upon the choice of platform used for HTT. The
candidate shall provide bioinformatics support for large scale high
throughput transcriptomics studies such as the S1500+ platform (See
Ramaiahgari et al (2019) Tox Sci 169:553-566). The candidate may
provide bioinformatics support for approximately 3-5 high (and/or
medium) throughput transcriptomics studies per year.
Supporting design for studiesIt is
anticipated that, unique/new study designs or experiment types may
be adopted by the client, which may require bioinformatics analysis
methods specific to these designs. The candidate contribution to
study design shall include but is not limited to types of data
reduction methods employed such as clustering analysis and/or data
visualization, pathway analysis employed (such as KEGG pathways
Kyoto Encyclopedia of Genes and Genomes), IPA (Ingenuity Pathway
Analysis, Qiagen) analysis and/or GSEA (Gene Set Enrichment
Analysis) and/or SVM (support vector machine) analysis. The
candidate shall provide a data management plan for studies as
required. The candidate may provide bioinformatic support for up to
approximately 3-4 study design or related projects per year.
Providing toxicology advice and
experience to staff for other toxicology-related tasks, as needed
This role may lead to publications and may require some travel to
present at industry conferences, such as the Society of Toxicology
Annual Meeting.
Qualifications
This successful candidate is expected to have the following
credentials.Education and Relevant Experience
MS in Toxicology or related field and
3 to 5 years of relevant experience in transcriptomics and
toxicogenomics and study design, orPhD in Toxicology or related
field and 0 to 3 years of relevant experience in transcriptomics
and toxicogenomics and study design (preferred) Other Desirable
Skills
- History of publications and presentations in the field of
toxicology
- Ability to work with client team members as well as other
contractor team members
- Exhibit excellent communications skills
- Experience with implementation of bioinformatics methods for
the application of text, information, and data mining techniques
within the environmental health sciences
- Programming skills preferably with R or SAS
- Experience with statistical analysis of longitudinal and
multivariate discrete data
- Familiarity with high throughput screening (HTS) data,
toxicology studies, machine learning and experimental design as
needed for genomics studies, dose-response, and environmental
health studies. No immigration support is available for this
position; therefore, candidates must be authorized to work in the
US without sponsorship support from ORAU. Relocation support is not
available.
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Keywords: Oak Ridge Associated Universities, Jacksonville , Toxicologist/Biostatistician, Other , Raleigh, North Carolina
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